Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing
SCIE
SCOPUS
- Title
- Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing
- Authors
- Kim, HJ; Hwang, BH; Lim, S; Choi, BH; Kang, SH; Cha, HJ
- Date Issued
- 2015-12
- Publisher
- ELSEVIER SCI LTD
- Abstract
- Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy-L-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications. (C) 2015 Elsevier Ltd. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36178
- DOI
- 10.1016/J.BIOMATERIALS.2015.08.055
- ISSN
- 0142-9612
- Article Type
- Article
- Citation
- BIOMATERIALS, vol. 72, page. 104 - 111, 2015-12
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.