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Cited 15 time in webofscience Cited 15 time in scopus
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Hybrid system for ex vivo hemorheological and hemodynamic analysis: a feasibility study SCIE SCOPUS

Title
Hybrid system for ex vivo hemorheological and hemodynamic analysis: a feasibility study
Authors
Yeom, EKang, YJLee, SJ
Date Issued
2015-06-19
Publisher
Nature Publishing Group
Abstract
Precise measurement of biophysical properties is important to understand the relation between these properties and the outbreak of cardiovascular diseases (CVDs). However, a systematic measurement for these biophysical parameters under in vivo conditions is nearly impossible because of complex vessel shape and limited practicality. In vitro measurements can provide more biophysical information, but in vitro exposure changes hemorheological properties. In this study, a hybrid system composed of an ultrasound system and microfluidic device is proposed for monitoring hemorheological and hemodynamic properties under more reasonable experimental conditions. Biophysical properties including RBC aggregation, viscosity, velocity, and pressure of blood flows are simultaneously measured under various conditions to demonstrate the feasibility and performance of this measurement system. The proposed technique is applied to a rat extracorporeal loop which connects the aorta and jugular vein directly. As a result, the proposed system is found to measure biophysical parameters reasonably without blood collection from the rat and provided more detailed information. This hybrid system, combining ultrasound imaging and microfluidic techniques to ex vivo animal models, would be useful for monitoring the variations of biophysical properties induced by chemical agents. It can be used to understand the relation between biophysical parameters and CVDs.
URI
https://oasis.postech.ac.kr/handle/2014.oak/36238
DOI
10.1038/SREP11064
ISSN
2045-2322
Article Type
Article
Citation
Scientific Reports, vol. 5, page. 11064, 2015-06-19
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이상준LEE, SANG JOON
Dept of Mechanical Enginrg
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