DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, H | - |
dc.contributor.author | Lee, JC | - |
dc.contributor.author | Kwon, JH | - |
dc.contributor.author | Kim, KC | - |
dc.contributor.author | Cho, MS | - |
dc.contributor.author | Yang, YS | - |
dc.contributor.author | Oh, W | - |
dc.contributor.author | Choi, SJ | - |
dc.contributor.author | Seo, ES | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Wang, TJ | - |
dc.contributor.author | Hong, YM | - |
dc.date.accessioned | 2017-07-19T12:40:30Z | - |
dc.date.available | 2017-07-19T12:40:30Z | - |
dc.date.created | 2016-02-29 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36249 | - |
dc.description.abstract | Pulmonary arterial hypertension (PAH) causes right ventricular failure due to a gradual increase in pulmonary vascular resistance. The purposes of this study were to confirm the engraftment of human umbilical cord blood-mesenchymal stem cells (hUCB-MSCs) placed in the correct place in the lung and research on changes of hemodynamics, pulmonary pathology, immunomodulation and several gene expressions in monocrotaline (MCT)induced PAH rat models after hUCB-MSCs transfusion. The rats were grouped as follows: the control (C) group; the M group (MCT 60 mg/kg); the U group (hUCB-MSCs transfusion). They received transfusions via the external jugular vein a week after MCT injection. The mean right ventricular pressure (RVP) was significantly reduced in the U group after the 2 week. The indicators of RV hypertrophy were significantly reduced in the U group at week 4. Reduced medial wall thickness in the pulmonary arteriole was noted in the U group at week 4. Reduced number of intra-acinar muscular pulmonary arteries was observed in the U group after 2 week. Protein expressions such as endothelin (ET)-1, endothelin receptor A (ERA), endothelial nitric oxide synthase (eNOS) and matrix metalloproteinase (MMP)-2 significantly decreased at week 4. The decreased levels of ERA, eNOS and MMP-2 immunoreactivity were noted by immnohistochemical staining. After hUCB-MSCs were administered, there were the improvement of RVH and mean RVP. Reductions in several protein expressions and immunomodulation were also detected. It is suggested that hUCB-MSCs may be a promising therapeutic option for PAH. | - |
dc.language | English | - |
dc.publisher | 대한의학회 | - |
dc.relation.isPartOf | Journal of Korean Medical Science | - |
dc.title | The effect of umbilical cord blood derived mesenchymal stem cells in monocrotaline-induced pulmonary artery hypertension rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/JKMS.2015.30.5.576 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.30, no.5, pp.576 - 585 | - |
dc.identifier.wosid | 000354981600010 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 585 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 576 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Lee, SJ | - |
dc.identifier.scopusid | 2-s2.0-84952017017 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 7 | - |
dc.description.scptc | 4 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | LUNG EPITHELIUM | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PARACRINE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Pulmonary | - |
dc.subject.keywordAuthor | Monocrotaline | - |
dc.subject.keywordAuthor | Cord Blood Stem Cell Transfusion | - |
dc.subject.keywordAuthor | Gene Expression | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
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