DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J | - |
dc.contributor.author | Park, H | - |
dc.contributor.author | Kim, WJ | - |
dc.date.accessioned | 2017-07-19T12:42:47Z | - |
dc.date.available | 2017-07-19T12:42:47Z | - |
dc.date.created | 2016-01-26 | - |
dc.date.issued | 2015-10-21 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36302 | - |
dc.description.abstract | A majority of the photo-responsive drug-delivery systems that are currently being studied require a complicated synthesis method. Here, we prepare a near-infrared responsive, photothermally controllable, drug-delivery carrier by a simple mixing and extraction process without the incorporation of toxic chemicals. A blend of doxorubicin (DOX), an anticancer drug, and a phase-change material (PCM) are loaded onto the mesoporous structure of silica-coated graphene oxide (GO@MS) to form a waffle-like structure, which is confirmed by various physicochemical analyses. The cytotoxicity of DOX/PCM-loaded GO@MS (DOX/PCM-GO@MS) against HeLa cells is 50 times higher than that of free DOX, and this improved activity can be attributed to the photothermal effectiveness of GO@MS. Additionally, the cytotoxicity and uptake mechanism of the PCM-based material are analyzed by flow cytometry. Taken together, our results suggest an enormous potential for spatio-temporal control in photothermally responsive drug-delivery systems. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | SMALL | - |
dc.title | Nano Chocolate Waffle for near-IR Responsive Drug Releasing System | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/SMLL.201403228 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | SMALL, v.11, no.39, pp.5315 - 5323 | - |
dc.identifier.wosid | 000363204500015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 5323 | - |
dc.citation.number | 39 | - |
dc.citation.startPage | 5315 | - |
dc.citation.title | SMALL | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Kim, WJ | - |
dc.identifier.scopusid | 2-s2.0-84944278159 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 10 | - |
dc.description.scptc | 8 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CELLULAR UPTAKE MECHANISM | - |
dc.subject.keywordPlus | PHASE-CHANGE MATERIALS | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | INTRACELLULAR FATE | - |
dc.subject.keywordPlus | GRAPHENE OXIDE | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | INTERNALIZATION | - |
dc.subject.keywordAuthor | nanostructures | - |
dc.subject.keywordAuthor | graphene oxide | - |
dc.subject.keywordAuthor | mesoporous silica | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | photothermal materials | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
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