DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Kim, H | - |
dc.contributor.author | Park, Y | - |
dc.contributor.author | Kong, WH | - |
dc.contributor.author | LEE, SEUNG WOO | - |
dc.contributor.author | Kwok, SJJ | - |
dc.contributor.author | Hahn, SK | - |
dc.contributor.author | Yun, SH | - |
dc.date.accessioned | 2017-07-19T12:47:28Z | - |
dc.date.available | 2017-07-19T12:47:28Z | - |
dc.date.created | 2016-05-26 | - |
dc.date.issued | 2016-04-19 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36446 | - |
dc.description.abstract | Vaccines are commonly administered by injection using needles. Although transdermal microneedles are less invasive promising alternatives, needle-free topical vaccination without involving physical damage to the natural skin barrier is still sought after as it can further reduce needle-induced anxiety and is simple to administer. However, this long-standing goal has been elusive since the intact skin is impermeable to most macromolecules. Here, we show an efficient, noninvasive transdermal vaccination by employing two key innovations: the use of hyaluronan (HA) as vaccine carriers and non-ablative laser adjuvants. Conjugates of a model vaccine ovalbumin (OVA) and HAHA-OVA conjugates-induced more effective maturation of dendritic cells in vitro, compared to OVA. Following topical administration in the skin, HA-OVA conjugates penetrated into the epidermis and dermis in murine and porcine skins, as revealed by intravital microscopy and fluorescence assay. Topical administration of HA-OVA conjugates significantly elevated both humoral and mucosal antibodies, with peak levels at four weeks. An OVA challenge at week eight elicited strong immune-recall responses. With pretreatment of the skin using non-ablative fractional laser beams as adjuvant, strong immunization was achieved with much reduced doses of HA-OVA (1 mg kg(-1) OVA). Our results demonstrate the potential of the noninvasive patch-type transdermal vaccination platform. | - |
dc.language | English | - |
dc.publisher | Wiley Online Library | - |
dc.relation.isPartOf | Advanced Functional Materials | - |
dc.title | Noninvasive Transdermal Vaccination Using Hyaluronan Nanocarriers and Laser Adjuvant | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ADFM.201504879 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Advanced Functional Materials, v.26, no.15, pp.2512 - 2522 | - |
dc.identifier.wosid | 000375126400012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 2522 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 2512 | - |
dc.citation.title | Advanced Functional Materials | - |
dc.citation.volume | 26 | - |
dc.contributor.affiliatedAuthor | LEE, SEUNG WOO | - |
dc.contributor.affiliatedAuthor | Hahn, SK | - |
dc.identifier.scopusid | 2-s2.0-84963864421 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 10 | - |
dc.description.scptc | 9 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DERMAL DENDRITIC CELLS | - |
dc.subject.keywordPlus | TRANSCUTANEOUS DRUG | - |
dc.subject.keywordPlus | IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | NEEDLE PHOBIA | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | IMMUNIZATION | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | VACCINES | - |
dc.subject.keywordPlus | OLIGOSACCHARIDES | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
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