N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway
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- Title
- N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway
- Authors
- Lee, KE; Heo, JE; Hwang, CS; KIM, JEONG MOK
- Date Issued
- 2016-03
- Publisher
- 한국분자세포생물학회
- Abstract
- Although N-terminal acetylation (Nt-acetylation) is a pervasive protein modification in eukaryotes, its general functions in a majority of proteins are poorly understood. In 2010, it was discovered that Nt-acetylation creates a specific protein degradation signal that is targeted by a new class of the N-end rule proteolytic system, called the Ac/N-end rule pathway. Here, we review recent advances in our understanding of the mechanism and biological functions of the Ac/N-end rule pathway, and its crosstalk with the Arg/N-end rule pathway (the classical N-end rule pathway).
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36471
- DOI
- 10.14348/MOLCELLS.2016.2329
- ISSN
- 1016-8478
- Article Type
- Article
- Citation
- Molecules and Cells, vol. 39, no. 3, page. 169 - 178, 2016-03
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