DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J | - |
dc.contributor.author | Lee, YM | - |
dc.contributor.author | Kim, WJ | - |
dc.date.accessioned | 2017-07-19T12:57:49Z | - |
dc.date.available | 2017-07-19T12:57:49Z | - |
dc.date.created | 2016-12-30 | - |
dc.date.issued | 2016-06-14 | - |
dc.identifier.issn | 0897-4756 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36698 | - |
dc.description.abstract | We demonstrate a new concept of a molecular net for capturing, release, and transportation of target molecules by utilizing polymer-based DNA molecular net (PD-mn). Target biomolecules like DNA, ATP, and VEGF were successfully captured from a heterogeneous mixture of biomolecules and released by a stimulus without nonspecific degradation by PD-mn prepared by polymerization of acrylamide and acrydite-modified DNA. Furthermore, by introducing fluorescence-labeled competitor DNA, single-mismatched DNA was specifically detected. As a concept of artificial transporter, PD-mn selectively captured target biomolecules from a heterogeneous mixture of molecules into a specific enzymatic reaction solution and induced enzyme-mediated reaction. Finally, effective in vivo antitumor effect was demonstrated utilizing sheet-shaped PD-mn which has improved capture ability against VEGF as a target biomolecule by amplified DNA VEGF aptamer. This PD-mn could be used as not only a selective molecular adsorbent or artificial transporter for specific capture and release of target molecules but also therapeutics by specific capture of disease-related molecules. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | CHEMISTRY OF MATERIALS | - |
dc.title | Polymer-DNA Molecular Net for Selective Transportation of Target Biomolecules and Inhibition of Tumor Growth | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.chemmater.6b01267 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CHEMISTRY OF MATERIALS, v.28, no.11, pp.3961 - 3967 | - |
dc.identifier.wosid | 000378016400049 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 3967 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3961 | - |
dc.citation.title | CHEMISTRY OF MATERIALS | - |
dc.citation.volume | 28 | - |
dc.contributor.affiliatedAuthor | Kim, WJ | - |
dc.identifier.scopusid | 2-s2.0-84975041166 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.description.scptc | 3 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HYDROGEL BIOMATERIALS | - |
dc.subject.keywordPlus | CAPTURE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | OLIGONUCLEOTIDES | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | BEVACIZUMAB | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
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