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Cited 13 time in webofscience Cited 14 time in scopus
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Construction of Large-Volume Tissue Mimics with 3D Functional Vascular Networks SCIE SCOPUS

Title
Construction of Large-Volume Tissue Mimics with 3D Functional Vascular Networks
Authors
Kang, TYHong, JMJung, JWKang, HWCho, DW
Date Issued
2016-05-26
Publisher
Public Library of Science
Abstract
We used indirect stereolithography (SL) to form inner-layered fluidic networks in a porous scaffold by introducing a hydrogel barrier on the luminal surface, then seeded the networks separately with human umbilical vein endothelial cells and human lung fibroblasts to form a tissue mimic containing vascular networks. The artificial vascular networks provided channels for oxygen transport, thus reducing the hypoxic volume and preventing cell death. The endothelium of the vascular networks significantly retarded the occlusion of channels during whole-blood circulation. The tissue mimics have the potential to be used as an in vitro platform to examine the physiologic and pathologic phenomena through vascular architecture.
URI
https://oasis.postech.ac.kr/handle/2014.oak/37011
DOI
10.1371/journal.pone.0156529
ISSN
1932-6203
Article Type
Article
Citation
PLoS ONE, vol. 11, no. 5, 2016-05-26
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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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