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Cited 28 time in webofscience Cited 30 time in scopus
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Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides SCIE SCOPUS

Title
Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides
Authors
Murat ArtanDae-Eun JeongDongyeop LeeYoung-Il KimHeehwa G. SonZahabiya HusainJinmahn KimOzlem AltintasKyuhyung KimJoy AlcedoLee, SJV
Date Issued
2016-05-01
Publisher
Cold Spring Harbor Laboratory Press
Abstract
Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans' life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs.
URI
https://oasis.postech.ac.kr/handle/2014.oak/37142
DOI
10.1101/GAD.279448.116
ISSN
0890-9369
Article Type
Article
Citation
Genes and Development, vol. 30, no. 9, page. 1047 - 1057, 2016-05-01
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이승재LEE, SEUNG JAE
Dept of Life Sciences
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