Visualization of pharmaceutical drug molecules by terahertz chemical imaging

Abstract

Terahertz spectroscopy allows the detection and identification of various molecular networks of chemical bond interactions, including those of hydrogen bonds. In this article, we explain terahertz time-domain spectroscopy, the principles of terahertz chemical imaging, and a multicomponent quantitative analysis method for amino acids that can visualize pharmaceutical crystalline polymorphs as an example of this technology.