DC Field | Value | Language |
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dc.contributor.author | Lee, SY | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Park, SJ | - |
dc.contributor.author | Kim, DJ | - |
dc.contributor.author | Kim, EK | - |
dc.contributor.author | Kim, JK | - |
dc.contributor.author | Yang, SH | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Kim, HY | - |
dc.contributor.author | Cho, ML | - |
dc.date.accessioned | 2017-07-19T13:44:14Z | - |
dc.date.available | 2017-07-19T13:44:14Z | - |
dc.date.created | 2017-02-22 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/37489 | - |
dc.description.abstract | IL-12p40 homodimer, a natural antagonist of IL-12 and IL-23, performs an important role in the expression of proinflammatory cytokines that is essential for Th1 and Th17 immune responses. Here, we reveal the therapeutic and immunosuppressive effect of the IL-12p40 subunit ((p40)(2)-Fc) in an experimental autoimmune arthritis model. We hypothesized that (p40)(2)-Fc may reduce the inflammatory response and the activation of T cells. In this study, we intraperitoneally injected (p40)(2)-Fc into collagen induced arthritis (CIA) mice to identify whether (p40)(2)-Fc attenuates CIA severity. (p40)(2)-Fc reduced the development of CIA, joint inflammation and cartilage destruction. (p40)(2)-Fc also significantly decreased the concentration of serum immunoglobulin as well as the number of T cells and C II specific T cells. In addition, osteoclastogenesis in (p40)(2)-Fc treated mice was down-regulated compared to the mice treated with (p40)(2)-Fc control. We observed that (p40)(2)-Fc treatment alleviates arthritis in mice with CIA, reducing inflammation and osteoclast differentiation. These findings suggest that (p40)(2)-Fc can be a potential therapeutic approach for autoimmune arthritis. (C) 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | Immunology Letters | - |
dc.title | (p40)2-Fc reduces immune-inflammatory response through the activation of T cells in collagen induced arthritis mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/J.IMLET.2016.05.013 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Immunology Letters, v.176, pp.36 - 43 | - |
dc.identifier.wosid | 000381324400005 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 43 | - |
dc.citation.startPage | 36 | - |
dc.citation.title | Immunology Letters | - |
dc.citation.volume | 176 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-84973169215 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 1 | - |
dc.description.scptc | 1 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | NECROSIS-FACTOR | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | IL-17 | - |
dc.subject.keywordAuthor | (p40)2-Fc | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Osteoclastogenesis | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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