DC Field | Value | Language |
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dc.contributor.author | Kim, JH | - |
dc.contributor.author | Choi, YJ | - |
dc.contributor.author | Lee, BH | - |
dc.contributor.author | Song, MY | - |
dc.contributor.author | Ban, CY | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Park, J | - |
dc.contributor.author | Kim, SE | - |
dc.contributor.author | Kim, TG | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Kim, HP | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Kim, SC | - |
dc.contributor.author | Shin, EC | - |
dc.date.accessioned | 2017-07-19T13:45:18Z | - |
dc.date.available | 2017-07-19T13:45:18Z | - |
dc.date.created | 2017-02-22 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/37525 | - |
dc.description.abstract | Background: Psoriasis is one of the most common chronic inflammatory diseases of the skin. Recently, IL-17-producing T cells have been shown to play a critical role in psoriatic inflammation. Programmed cell death 1 (PD-1) is a coinhibitory receptor expressed on T cells in various chronic inflammatory diseases; however, the expression and function of PD-1 during psoriatic inflammation have not previously been characterized. Objective: We examined PD-1 expression on IL-17A-producing T cells from imiquimod-treated mice and patients with psoriasis. Additionally, we investigated the therapeutic effect of recombinant programmed cell death ligand 1 (PD-L1) protein on imiquimod-induced psoriatic inflammation. Methods: PD-1 expression on IL-17A-producing gamma delta T cells from imiquimod-treated mice was examined by means of multicolor flow cytometric analysis. In the psoriatic skin of patients, PD-1 and IL-17A expression was analyzed by using immunofluorescence. The therapeutic effect of PD-L1-Fc fusion protein (PD-L1-Fc) was assessed in imiquimod-treated mice ex vivo and in vivo. Results: During imiquimod-induced psoriatic inflammation, PD-1 is overexpressed on CD27(-)V gamma 1(-) gamma delta T cells. Furthermore, PD-1 expression on IL-17A(+) T cells was confirmed in psoriatic skin tissues from patients and imiquimod-treated mice. In the CD27(-)V gamma 1(-) gamma delta T-cell population, V gamma 4(-) gamma delta T cells with V gamma 6 mRNA expression showed a high level of PD-1 expression. Furthermore, these PD-1(hi)V gamma 4(-)(V gamma 6(+)) gamma delta Tcells were specialized for anti-CD3-induced IL-17A production, which was inhibited by PD-L1-Fc treatment. In imiquimod-treated mice PD-L1-Fc reduced psoriatic inflammation when given alone and enhanced the therapeutic effect of anti-p40 when given in combination. Conclusion: PD-1 is overexpressed in IL-17A-producing T cells in both imiquimod-treated mice and patients with psoriasis. Moreover, recombinant PD-L1-Fc alleviates psoriatic inflammation in imiquimod-treated mice. | - |
dc.language | English | - |
dc.publisher | American Academy of Allergy Asthma & Immunology | - |
dc.relation.isPartOf | Journal of Allergy and Clinical Immunology | - |
dc.title | Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/J.JACI.2015.11.021 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of Allergy and Clinical Immunology, v.135, no.5, pp.1466 - U265 | - |
dc.identifier.wosid | 000376180200023 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | U265 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1466 | - |
dc.citation.title | Journal of Allergy and Clinical Immunology | - |
dc.citation.volume | 135 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-84955611917 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 19 | - |
dc.description.scptc | 12 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SKIN INFLAMMATION | - |
dc.subject.keywordPlus | PD-1 PATHWAY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | USTEKINUMAB | - |
dc.subject.keywordPlus | IMMUNOLOGY | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | BLOCKADE | - |
dc.subject.keywordAuthor | Psoriasis | - |
dc.subject.keywordAuthor | programmed cell death 1 | - |
dc.subject.keywordAuthor | programmed cell death ligand 1 | - |
dc.subject.keywordAuthor | IL-17A | - |
dc.subject.keywordAuthor | T cell | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
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