The aged lymphoid tissue environment fails to support naive T cell homeostasis.
SCIE
SCOPUS
- Title
- The aged lymphoid tissue environment fails to support naive T cell homeostasis.
- Authors
- Becklund, Bryan R.; Purton, Jared F.; Ramsey, Chris; Favre, Stephanie; Vogt, Tobias K.; Martin, Christopher E.; Spasova, Darina S.; Sarkisyan, Gor; LeRoy, Eric; Tan, Joyce T.; Wahlus, Heidi; Bondi-Boyd, Brea; Luther, Sanjiv A.; Surh, CD
- Date Issued
- 2016-08-02
- Publisher
- Nature Publishing Group
- Abstract
- Aging is associated with a gradual loss of naive T cells and a reciprocal increase in the proportion of memory T cells. While reduced thymic output is important, age-dependent changes in factors supporting naive T cells homeostasis may also be involved. Indeed, we noted a dramatic decrease in the ability of aged mice to support survival and homeostatic proliferation of naive T cells. The defect was not due to a reduction in IL-7 expression, but from a combination of changes in the secondary lymphoid environment that impaired naive T cell entry and access to key survival factors. We observed an age-related shift in the expression of homing chemokines and structural deterioration of the stromal network in T cell zones. Treatment with IL-7/mAb complexes can restore naive T cell homeostatic proliferation in aged mice. Our data suggests that homeostatic mechanisms that support the naive T cell pool deteriorate with age.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/37628
- DOI
- 10.1038/SREP30842
- ISSN
- 2045-2322
- Article Type
- Article
- Citation
- Scientific Reports, vol. 6, 2016-08-02
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