DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이창섭 | - |
dc.contributor.author | 김재왕 | - |
dc.contributor.author | 송박용 | - |
dc.contributor.author | 서판길 | - |
dc.contributor.author | 류성호 | - |
dc.date.accessioned | 2017-07-19T13:48:55Z | - |
dc.date.available | 2017-07-19T13:48:55Z | - |
dc.date.created | 2017-02-27 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/37655 | - |
dc.description.abstract | Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and critical for normal embryonic development and repair of pathophysiological conditions in adults. Although phospholipase D (PLD) activity has been implicated in angiogenic processes, its role in VEGF signaling during angiogenesis in mammals is unclear. Here, we found that silencing of PLD2 by siRNA blocked VEGF-mediated signaling in immortalized human umbilical vein endothelial cells (iHUVECs). Also, VEGF-induced endothelial cell survival, proliferation, migration, and tube formation were inhibited by PLD2 silencing. Furthermore, while Pld2-knockout mice exhibited normal development, loss of PLD2 inhibited VEGF-mediated ex vivo angiogenesis. These findings suggest that PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells. | - |
dc.language | English | - |
dc.publisher | 생화학분자생물학회 | - |
dc.relation.isPartOf | BMB Reports | - |
dc.title | Loss of phospholipase D2 impairs VEGF-induced angiogenesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.5483/BMBREP.2016.49.3.219 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BMB Reports, v.49, no.3, pp.191 - 196 | - |
dc.identifier.kciid | ART002092078 | - |
dc.identifier.wosid | 000373059900010 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 196 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 191 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 49 | - |
dc.contributor.affiliatedAuthor | 류성호 | - |
dc.identifier.scopusid | 2-s2.0-84964412347 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 5 | - |
dc.description.scptc | 4 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | RECEPTOR TYROSINE-KINASE | - |
dc.subject.keywordPlus | ADAPTER PROTEIN | - |
dc.subject.keywordPlus | DNA-SYNTHESIS | - |
dc.subject.keywordPlus | KDR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | AUTOPHOSPHORYLATION | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | LETHALITY | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Aorta ring | - |
dc.subject.keywordAuthor | Endothelial cells | - |
dc.subject.keywordAuthor | Phospholipase D | - |
dc.subject.keywordAuthor | Tube formation | - |
dc.subject.keywordAuthor | VEGF | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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