DC Field | Value | Language |
---|---|---|
dc.contributor.author | Minsuk Choi | - |
dc.contributor.author | Sang Ho Lee | - |
dc.contributor.author | Kim, WB | - |
dc.contributor.author | Vipul Gujrati | - |
dc.contributor.author | Daejin Kim | - |
dc.contributor.author | Jinju Lee | - |
dc.contributor.author | Jae-Il Kim | - |
dc.contributor.author | Hyungjun Kim | - |
dc.contributor.author | Phei Er Saw | - |
dc.contributor.author | Sangyong Jon | - |
dc.date.accessioned | 2017-07-19T13:56:48Z | - |
dc.date.available | 2017-07-19T13:56:48Z | - |
dc.date.created | 2017-02-28 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/37913 | - |
dc.description.abstract | There is considerable interest in developing a common, universal platform for delivering biomacromolecules such as proteins and RNAs into diverse cells with high efficiency. Here, it is shown that carbon nanosyringe arrays (CNSAs) under an applied centrifugal g-force (cf-CNSAs) can deliver diverse bioactive cargos directly into the cytosol of hard-to-transfect cells with relatively high efficiency and reproducibility. The cf-CNSA platform, an optimized version of a previous CNSA-mediated intracellular delivery platform that adds a g-force feature, exhibits more rapid and superior delivery of cargos to various hard-to-transfect cells than is the case in the absence of g-force. Active species, including small interfering RNAs, plasmids, and proteins are successfully transported across plasma membrane barriers into various cells. By overcoming the limitations of currently available transfection methods, the cf-CNSA platform paves the way to universal delivery of a variety of cargos, facilitating the analysis of cellular responses in diverse cell types. | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | Advanced Healthcare Materials | - |
dc.title | Intracellular Delivery of Bioactive Cargos to Hard-to-Transfect Cells Using Carbon Nanosyringe Arrays under an Applied Centrifugal g-Force | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ADHM.201400834 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Advanced Healthcare Materials, v.5, no.1, pp.101 - 107 | - |
dc.identifier.wosid | 000368144200008 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 107 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 101 | - |
dc.citation.title | Advanced Healthcare Materials | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Kim, WB | - |
dc.identifier.scopusid | 2-s2.0-84953840404 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 6 | - |
dc.description.scptc | 5 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN TRANSDUCTION | - |
dc.subject.keywordPlus | GENE-THERAPY | - |
dc.subject.keywordPlus | ELECTROPORATION | - |
dc.subject.keywordPlus | PERSPECTIVES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | REAGENT | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | SIRNA | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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