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Cited 23 time in webofscience Cited 23 time in scopus
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Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging SCIE SCOPUS

Title
Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging
Authors
Wang, TJANG, WON HYUKLee, SYoon, CJLee, JHKim, BHwang, SHong, CPYoon, YLee, GLe, VHBok, SAHN, G ONELee, JGho, YSChung, EKIM, SUNGJEEJang, MHMyung, SJKim, MJSo, PTCKIM, KI HEAN
Date Issued
2016-06-10
Publisher
NATURE PUBLISHING GROUP
Abstract
Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenous fluorescence in tissue and cytotoxicity of exogenous probes. Herein, we describe the applications of moxifloxacin, an FDA-approved antibiotic, as a cell-labeling agent for MPM. Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue penetration and high intracellular concentration. MPM with moxifloxacin was demonstrated in various cell lines, and animal tissues of cornea, skin, small intestine and bladder. Clinical application is promising since imaging based on moxifloxacin labeling could be 10 times faster than imaging based on endogenous fluorescence.
URI
https://oasis.postech.ac.kr/handle/2014.oak/37973
DOI
10.1038/SREP27142
ISSN
2045-2322
Article Type
Article
Citation
Scientific Reports, vol. 6, page. 27142, 2016-06-10
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김기현KIM, KI HEAN
Dept of Mechanical Enginrg
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