Efficacy of thyroid ultrasound elastography in differential diagnosis of small thyroid nodules
SCIE
SCOPUS
- Title
- Efficacy of thyroid ultrasound elastography in differential diagnosis of small thyroid nodules
- Authors
- Dighe, Manjiri; Luo, Si; Cuevas, Carlos; Kim, Y
- Date Issued
- 2013-06
- Publisher
- ELSEVIER
- Abstract
- Objective: To explore the efficacy of thyroid ultrasound (US) elastography in differential diagnosis of small thyroid nodules. Methods: This HIPAA-compliant study was approved by the Institutional Review Board and all patients provided written informed consent. Thirty-five patients with 38 small thyroid nodules as seen on transverse ultrasound image formed our study population. An US examination and a separate thyroid elastography examination with pulsation from the carotid artery used as the compression source were performed before fine-needle aspiration. Baseband US data were acquired for off-line elastography processing, where a semi-quantitative index for each nodule was calculated. The Kruskal-Wallis non-parametric rank sum test was used to assess equality of population means among the different types of thyroid nodules. Maximum likelihood estimation of the curve parameters for a binomial receiver operating characteristic (ROC) curve was performed. Results: Elasticity contrast index calculated with elastography was effective in distinguishing between small papillary thyroid carcinomas (PTMC, n = 8) and other lesions (n = 30) in small thyroid nodules (p = 0.0036). The area under the ROC curve for diagnosing PTMCs was 0.812 with a 95% confidence interval of 0.653-0.920. The cut-off value of ECI of 3.6 led to a sensitivity of 100% and a specificity of 60% for detecting PTMCs. Conclusion: Noninvasive evaluation of small thyroid nodules is possible using thyroid US elastography with in vivo compression to pick out the most suspicious thyroid nodules for fine-needle aspiration (FNA) and avoid FNA in benign nodules. Published by Elsevier Ireland Ltd
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/38146
- DOI
- 10.1016/J.EJRAD.2013.01.009
- ISSN
- 0720-048X
- Article Type
- Article
- Citation
- European Journal of Radiology, vol. 82, no. 6, page. E274 - E280, 2013-06
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