DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Y.R | - |
dc.contributor.author | Song, S | - |
dc.contributor.author | Hwang, H | - |
dc.contributor.author | Jung, J.H | - |
dc.contributor.author | Kim, S.-J | - |
dc.contributor.author | Yoon, S | - |
dc.contributor.author | Hur, J.-H | - |
dc.contributor.author | Park, J.-I | - |
dc.contributor.author | Lee, C | - |
dc.contributor.author | Nam, D | - |
dc.contributor.author | Seo, Y.-K | - |
dc.contributor.author | Kim, J.-H | - |
dc.contributor.author | Rhim, H | - |
dc.contributor.author | Suh, P.-G. | - |
dc.date.accessioned | 2017-07-19T14:09:54Z | - |
dc.date.available | 2017-07-19T14:09:54Z | - |
dc.date.created | 2017-04-06 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/38149 | - |
dc.description.abstract | O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga(+/-)mice which have an increased level of O-GlcNAcylation, and found that Oga(+/-)mice exhibited impaired spatial learning and memory. Consistent with this result, Oga(+/-)mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-OGlcNAcylation in learning and memory. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.title | Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/SREP44921 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.7, pp.44921 | - |
dc.identifier.wosid | 000398105100001 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.startPage | 44921 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Kim, J.-H | - |
dc.identifier.scopusid | 2-s2.0-85016960086 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 6 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | ARTICLE | - |
dc.subject.keywordPlus | PARTICLE-SIZE DISTRIBUTION | - |
dc.subject.keywordPlus | BINDER SEPARATION | - |
dc.subject.keywordPlus | TITANIUM | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | ALLOY | - |
dc.subject.keywordPlus | PARTS | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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