Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases
SCIE
SCOPUS
- Title
- Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases
- Authors
- YUN, EUN JIN; Song, Kyoung Sub; Shin, Soyeon; Kim, Soyeon; Heo, Jun-Young; Kweon, Gi Ryang; Wu, Tong; Park, Jong-Il; Lim, Kyu
- Date Issued
- 2016-08-02
- Publisher
- IMPACT JOURNALS LLC
- Abstract
- Breast cancer is one of the most prevalent cancers in women, and nearly half of breast cancer patients develop distant metastatic disease after therapy. Despite the significant advances that have been achieved in understanding breast cancer metastasis in the past decades, metastatic cancer is still hard to cure. Here, we demonstrated an anti-cancer mechanism of docosahexaenoic acid (DHA) that suppressed lung metastasis in breast cancer. DHA could inhibit proliferation and invasion of breast cancer cells in vitro, and this was mainly through blocking Cox-2-PGE 2 -NF-kappa B-MMPs cascades. DHA treatment significantly decreased Cox-2 and NF-kappa B expression as well as nuclear translocation of NF-kappa B in MDA-MB-231 cells. In addition, DHA also reduced NF-kappa B binding to DNA which may lead to inactivation of MMPs. Moreover, in vivo studies using Fat-1 transgenic mice showed remarkable decrease of tumor growth and metastasis to EO771 cells to lung in DHA-rich environment. In conclusion, DHA attenuated breast cancer progression and lung metastasis in part through suppressing MMPs, and these findings suggest chemoprevention and potential therapeutic strategy to overcome malignant breast cancer.
- Keywords
- NF-KAPPA-B; POLYUNSATURATED FATTY-ACIDS; SELECTIVE COX-2 INHIBITORS; MYOCARDIAL-INFARCTION; TUMOR-ANGIOGENESIS; GENE-EXPRESSION; N-3; INFLAMMATION; ACTIVATION; MECHANISM
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/39245
- DOI
- 10.18632/oncotarget.10266
- ISSN
- 1949-2553
- Article Type
- Article
- Citation
- Oncotarget, vol. 7, no. 31, page. 49961 - 49971, 2016-08-02
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- There are no files associated with this item.
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