DC Field | Value | Language |
---|---|---|
dc.contributor.author | YUN, EUN JIN | - |
dc.contributor.author | Song, Kyoung Sub | - |
dc.contributor.author | Shin, Soyeon | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Heo, Jun-Young | - |
dc.contributor.author | Kweon, Gi Ryang | - |
dc.contributor.author | Wu, Tong | - |
dc.contributor.author | Park, Jong-Il | - |
dc.contributor.author | Lim, Kyu | - |
dc.date.accessioned | 2018-01-04T11:17:11Z | - |
dc.date.available | 2018-01-04T11:17:11Z | - |
dc.date.created | 2017-11-13 | - |
dc.date.issued | 2016-08-02 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/39245 | - |
dc.description.abstract | Breast cancer is one of the most prevalent cancers in women, and nearly half of breast cancer patients develop distant metastatic disease after therapy. Despite the significant advances that have been achieved in understanding breast cancer metastasis in the past decades, metastatic cancer is still hard to cure. Here, we demonstrated an anti-cancer mechanism of docosahexaenoic acid (DHA) that suppressed lung metastasis in breast cancer. DHA could inhibit proliferation and invasion of breast cancer cells in vitro, and this was mainly through blocking Cox-2-PGE 2 -NF-kappa B-MMPs cascades. DHA treatment significantly decreased Cox-2 and NF-kappa B expression as well as nuclear translocation of NF-kappa B in MDA-MB-231 cells. In addition, DHA also reduced NF-kappa B binding to DNA which may lead to inactivation of MMPs. Moreover, in vivo studies using Fat-1 transgenic mice showed remarkable decrease of tumor growth and metastasis to EO771 cells to lung in DHA-rich environment. In conclusion, DHA attenuated breast cancer progression and lung metastasis in part through suppressing MMPs, and these findings suggest chemoprevention and potential therapeutic strategy to overcome malignant breast cancer. | - |
dc.language | English | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.relation.isPartOf | Oncotarget | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject | SELECTIVE COX-2 INHIBITORS | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | TUMOR-ANGIOGENESIS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | N-3 | - |
dc.subject | INFLAMMATION | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISM | - |
dc.title | Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.10266 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Oncotarget, v.7, no.31, pp.49961 - 49971 | - |
dc.identifier.wosid | 000385422000090 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 49971 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 49961 | - |
dc.citation.title | Oncotarget | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | YUN, EUN JIN | - |
dc.identifier.scopusid | 2-s2.0-84981342137 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | SELECTIVE COX-2 INHIBITORS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | N-3 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | DHA | - |
dc.subject.keywordAuthor | omega-3 PUFA | - |
dc.subject.keywordAuthor | MMP | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.