Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.
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SCOPUS
- Title
- Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.
- Authors
- Malhotra, D; Linehan, JL; Dileepan, T; Lee, YJ; Purtha, WE; Lu, JV; Nelson, RW; Fife, BT; Orr, HT; Anderson, MS; Hogquist, KA; Jenkins, MK
- Date Issued
- 2016-02
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Studies of repertoires of mouse monoclonal CD4(+) T cells have revealed several mechanisms of self-tolerance; however, which mechanisms operate in normal repertoires is unclear. Here we studied polyclonal CD4(+) T cells specific for green fluorescent protein expressed in various organs, which allowed us to determine the effects of specific expression patterns on the same epitope-specific T cells. Peptide's presented uniformly by thymic antigen-presenting cells were tolerated by clonal deletion, whereas peptides excluded from the thymus were ignored. Peptides with limited thymic expression induced partial clonal deletion and impaired effector T cell potential but enhanced regulatory T cell potential. These mechanisms were also active for T cell populations specific for endogenously expressed self antigens. Thus, the immunotolerance of polyclonal CD4(+) T cells was maintained by distinct mechanisms, according to self-peptide expression patterns.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/39289
- DOI
- 10.1038/NI.3327
- ISSN
- 1529-2908
- Article Type
- Article
- Citation
- NATURE IMMUNOLOGY, vol. 17, no. 2, page. 187 - 195, 2016-02
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- There are no files associated with this item.
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