DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, BH | - |
dc.contributor.author | Min, HS | - |
dc.contributor.author | Lee, YJ | - |
dc.contributor.author | Choi, B | - |
dc.contributor.author | Kim, EJ | - |
dc.contributor.author | Lee, J | - |
dc.contributor.author | Kim, JR | - |
dc.contributor.author | Cho, KH | - |
dc.contributor.author | Kim, TJ | - |
dc.contributor.author | Jung, KC | - |
dc.contributor.author | Park, SH | - |
dc.date.accessioned | 2018-01-05T01:25:25Z | - |
dc.date.available | 2018-01-05T01:25:25Z | - |
dc.date.created | 2017-07-16 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/39383 | - |
dc.description.abstract | Analysis of the T-cell receptor (TCR) repertoire of innate CD4(+) T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4(+) T cells) is essential for predicting the characteristics of the antigens that bind to these T cells and for distinguishing T-T CD4(+) T cells from other types of innate T cells. Using the TCRmini Tg mouse model, we show that the repertoire of TCR alpha chains in T-T CD4(+) T cells was extremely diverse, in contrast to the repertoires previously described for other types of innate T cells. The TCR alpha chain sequences significantly overlapped between T-T CD4(+) T cells and conventional CD4(+) T cells in the thymus and spleen. However, the diversity of the TCR alpha repertoire of T-T CD4(+) T cells seemed to be restricted compared with that of conventional CD4(+) T cells. Interestingly, the frequency of the parental OT-II TCR alpha chains was significantly reduced in the process of T-T interaction. This diverse and shifted repertoire in T-T CD4(+) T cells has biological relevance in terms of defense against diverse pathogens and a possible regulatory role during peripheral T-T interaction. | - |
dc.language | English | - |
dc.publisher | Nature publishing group | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.title | Analyses of the TCR repertoire in MHC class II-restricted innate CD4+ T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/EMM.2015.7 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.47, no.E154 | - |
dc.identifier.wosid | 000358592900011 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.number | E154 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 47 | - |
dc.contributor.affiliatedAuthor | Lee, YJ | - |
dc.identifier.scopusid | 2-s2.0-84965191423 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 3 | - |
dc.description.scptc | 3 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | THYMOCYTE-THYMOCYTE INTERACTION | - |
dc.subject.keywordPlus | POSITIVE SELECTION | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | SELF-PEPTIDES | - |
dc.subject.keywordPlus | ALPHA-CHAIN | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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