Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
SCOPUS
- Title
- Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
- Authors
- Jan Lötvall; Andrew F. Hill; Fred Hochberg; Edit I. Buzás; Dolores Di Vizio; Christopher Gardiner; Yong Song Gho; Igor V. Kurochkin; Suresh Mathivanan; Peter Quesenberry; Susmita Sahoo; Hidetoshi Tahara; Marca H. Wauben; Kenneth W. Witwer; Clotilde Théry
- Date Issued
- 2014-12
- Publisher
- Co-Action Publishing
- Abstract
- Secreted membrane-enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology and medicine. Importantly, it is currently technically challenging to obtain a totally pure EV fraction free from non-vesicular components for functional studies, and therefore there is a need to establish guidelines for analyses of these vesicles and reporting of scientific studies on EV biology. Here, the International Society for Extracellular Vesicles (ISEV) provides researchers with a minimal set of biochemical, biophysical and functional standards that should be used to attribute any specific biological cargo or functions to EVs. © 2014 Jan Lötvall et al.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/39425
- DOI
- 10.3402/jev.v3.26913
- ISSN
- 2001-3078
- Article Type
- Article
- Citation
- Journal of Extracellular Vesicles, vol. 3, no. 3, 2014-12
- Files in This Item:
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