DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, MS | - |
dc.contributor.author | Byun, MJ | - |
dc.contributor.author | Oh, BH | - |
dc.date.accessioned | 2018-01-09T09:01:34Z | - |
dc.date.available | 2018-01-09T09:01:34Z | - |
dc.date.created | 2017-08-03 | - |
dc.date.issued | 2003-08 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/40824 | - |
dc.description.abstract | The family of peptidoglycan recognition proteins (PGRPs) are associated with the recognition of the peptidoglycan of microbes and subsequent activation of signaling pathways for immune response. Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 Angstrom and shows an active-site cleft with a zinc cage. Poor conservation of surface residues at the cleft predicts a widely varying individual specificity of PGRPs for molecular patterns on microbial cell walls. At the back of this cleft is a putatively conserved distinctive groove. The location and mainly hydrophobic nature of the groove indicate that the back face serves for subsequent signaling after clustering of PGRP molecules by binding to polymeric cell wall components. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | NATURE IMMUNOLOGY | - |
dc.title | Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/ni952 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.4, no.8, pp.787 - 793 | - |
dc.identifier.wosid | 000184441500016 | - |
dc.citation.endPage | 793 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 787 | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 4 | - |
dc.contributor.affiliatedAuthor | Kim, MS | - |
dc.identifier.scopusid | 2-s2.0-0042195829 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | POSITIVE BACTERIAL-INFECTIONS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE REQUIRES | - |
dc.subject.keywordPlus | GRAM-NEGATIVE BACTERIA | - |
dc.subject.keywordPlus | KAPPA-B KINASE | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | ANTIBACTERIAL DEFENSE | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | BOMBYX-MORI | - |
dc.subject.keywordPlus | TOLL | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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