DC Field | Value | Language |
---|---|---|
dc.contributor.author | YUN, EUN JIN | - |
dc.contributor.author | Seo, Kang-Sik | - |
dc.contributor.author | Kim, Hoon | - |
dc.contributor.author | Hong, Tae-Hwa | - |
dc.contributor.author | Kim, Jong-Seok | - |
dc.contributor.author | Song, Kyoung-Sub | - |
dc.contributor.author | Park, Ji-Hoon | - |
dc.contributor.author | Jung, Young-Hoon | - |
dc.contributor.author | Park, Jong-Il | - |
dc.contributor.author | Kweon, Gi Ryang | - |
dc.contributor.author | Yoon, Wan-Hee | - |
dc.contributor.author | Lim, Kyu | - |
dc.contributor.author | Hwang, Byung-Doo | - |
dc.date.accessioned | 2018-01-09T09:03:47Z | - |
dc.date.available | 2018-01-09T09:03:47Z | - |
dc.date.created | 2017-11-13 | - |
dc.date.issued | 2013-05-10 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/40838 | - |
dc.description.abstract | Apicularen A is a novel antitumor agent and strongly induces death in tumor cells. In this study, we synthesized apicularen A acetate, an acetyl derivative of apicularen A, and investigated its antitumor effect and mechanism in HM7 colon cancer cells. Apicularen A acetate induced apoptotic cell death and caspase-3 activation; however, the pan-caspase inhibitor Z-VAD-fmk could not prevent this cell death. Apicularen A acetate induced the loss of mitochondrial membrane potential and the translocation of apoptosis-inducing factor (AIF) from mitochondria. In addition, apicularen A acetate significantly decreased tubulin mRNA and protein levels and induced disruption of microtubule networks. Taken together, these results indicate that the mechanism of apicularen A acetate involves caspase-independent apoptotic cell death and disruption of microtubule architecture. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | RAW-264.7 CELLS | - |
dc.subject | INDUCTION | - |
dc.subject | LINE | - |
dc.subject | FAS | - |
dc.subject | CASPASE-3 | - |
dc.title | Apicularen A acetate induced cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.03.133 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.434, no.3, pp.634 - 640 | - |
dc.identifier.wosid | 000319481500039 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 640 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 634 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 434 | - |
dc.contributor.affiliatedAuthor | YUN, EUN JIN | - |
dc.identifier.scopusid | 2-s2.0-84880482712 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | LINE | - |
dc.subject.keywordPlus | FAS | - |
dc.subject.keywordPlus | CASPASE-3 | - |
dc.subject.keywordAuthor | Apicularen A acetate | - |
dc.subject.keywordAuthor | Caspase-independent apoptosis | - |
dc.subject.keywordAuthor | Apoptosis-inducing factor | - |
dc.subject.keywordAuthor | Microtubule disruption | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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