DC Field | Value | Language |
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dc.contributor.author | YUN, EUN JIN | - |
dc.contributor.author | Song, Kyoung-Sub | - |
dc.contributor.author | Jing, Kaipeng | - |
dc.contributor.author | Kim, Jong-Seok | - |
dc.contributor.author | Shin, Soyeon | - |
dc.contributor.author | Seo, Kang-Sik | - |
dc.contributor.author | Park, Ji-Hoon | - |
dc.contributor.author | Heo, Jun-Young | - |
dc.contributor.author | Kang, Jing X. | - |
dc.contributor.author | Suh, Kwang-Sun | - |
dc.contributor.author | Wu, Tong | - |
dc.contributor.author | Park, Jong-Il | - |
dc.contributor.author | Kweon, Gi Ryang | - |
dc.contributor.author | Yoon, Wan-Hee | - |
dc.contributor.author | Hwang, Byung-Doo | - |
dc.contributor.author | Lim, Kyu | - |
dc.date.accessioned | 2018-01-09T09:03:59Z | - |
dc.date.available | 2018-01-09T09:03:59Z | - |
dc.date.created | 2017-11-14 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 1424-3903 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/40844 | - |
dc.description.abstract | Background/Aims: omega 3-polyunsaturated fatty acids (omega 3-PUFAs) are known to possess anticancer properties. However, the relationship between omega 3-PUFAs and beta-catenin, one of the key components of the Wnt signaling pathway, in human pancreatic cancer remains poorly characterized. Methods: Human pancreatic cancer cells (SW1990 and PANC-1) were exposed to two omega 3-PUFAs, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), to investigate the relationship between omega 3-PUFAs and the Wnt/beta-catenin signaling pathway in vitro. Mouse pancreatic cancer (PANC02) cells were implanted into fat-1 transgenic mice, which express omega 3 desaturases and result in elevated levels of omega 3-PUFAs endogenously. The tumor size, levels of Wnt/beta-catenin signaling molecules and apoptosis levels were analyzed to examine the influence of omega 3-PUFAs in vivo. Results: DHA and EPA significantly inhibited cell growth and increased cell death in pancreatic cancer cells. DHA also reduced beta-catenin expression, T cell factor/lymphoid-enhancing factor reporter activity and induced beta-catenin/Axin/GSK-3 beta complex formation, a known precursor to beta-catenin degradation. Furthermore, Wnt3a, a natural canonical Wnt pathway ligand, reversed DHA-induced growth inhibition in PANC-1 cells. Immunohistochemical analysis showed aberrant upregulation and increased nuclear staining of beta-catenin in tumor tissues from pancreatic cancer patients. However, beta-catenin levels in tumor tissues from fat-1 transgenic mice were reduced with a significant increase in apoptosis compared with those from control mice. Conclusion: omega 3-PUFAs may be an effective therapy for the chemoprevention and treatment of human pancreatic cancer. Copyright (C) 2011 S. Karger AG, Basel and IAP | - |
dc.language | English | - |
dc.publisher | KARGER | - |
dc.relation.isPartOf | PANCREATOLOGY | - |
dc.subject | BETA-CATENIN | - |
dc.subject | DOCOSAHEXAENOIC ACID | - |
dc.subject | WNT PATHWAY | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | COLON-CANCER | - |
dc.subject | TUMOR-CELLS | - |
dc.subject | APOPTOSIS | - |
dc.subject | OMEGA-3-FATTY-ACIDS | - |
dc.subject | EXPRESSION | - |
dc.subject | ACTIVATION | - |
dc.title | Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000334468 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PANCREATOLOGY, v.11, no.6, pp.574 - 584 | - |
dc.identifier.wosid | 000302126300006 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 584 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 574 | - |
dc.citation.title | PANCREATOLOGY | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | YUN, EUN JIN | - |
dc.identifier.scopusid | 2-s2.0-84855177053 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 45 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | WNT PATHWAY | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | omega 3-PUFAs | - |
dc.subject.keywordAuthor | Pancreatic cancer | - |
dc.subject.keywordAuthor | Wnt/beta-catenin | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
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