Development of Fluorination Methodology for Carbon-Fluorine Bond Formation: Nucleophilic Fluorinating Reagents in the Mid-2000s

Abstract

Since carbon–fluorine (C–F) bonds play a key role to improve bioavailability and lipophilicity, they have found commonly in pharmaceuticals, radiopharmaceuticals, agrochemicals, and material science. Advances on the efficient method to introduce fluorine to complex organic molecules are mainly results of development of fluorination reagents and transition metal catalysts. In this mini-review, we want to emphasize two representative nucleophilic fluorinating reagents regarding carbon–fluorine bond formation, which were developed in the mid2000s.