DC Field | Value | Language |
---|---|---|
dc.contributor.author | PARK, YOOJIN | - |
dc.contributor.author | NIM-ANUSSORNKUL, DUANGRAT | - |
dc.contributor.author | VILAIVAN, TIRAYUT | - |
dc.contributor.author | MORII, TAKASHI | - |
dc.contributor.author | KIM, BYEANG HYEAN | - |
dc.date.accessioned | 2018-05-03T09:36:12Z | - |
dc.date.available | 2018-05-03T09:36:12Z | - |
dc.date.created | 2018-02-22 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/41008 | - |
dc.description.abstract | We have developed RNA-based quencher-free molecular aptamer beacons (RNA-based QF-MABs) for the detection of ATP, taking advantage of the conformational changes associated with ATP binding to the ATP-binding RNA aptamer. The RNA aptamer, with its well-defined structure, was readily converted to the fluorescence sensors by incorporating a fluorophore into the loop region of the hairpin structure. These RNA-based QF-MABs exhibited fluorescence signals in the presence of ATP relative to their low background signals in the absence of ATP. The fluorescence emission intensity increased upon formation of a RNA-based QF-MAB·ATP complex. © 2017 Elsevier Ltd | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.title | Facile conversion of ATP-binding RNA aptamer to quencher-free molecular aptamer beacon | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bmcl.2017.12.008 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.28, no.2, pp.77 - 80 | - |
dc.identifier.wosid | 000423658000004 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 80 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 77 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 28 | - |
dc.contributor.affiliatedAuthor | PARK, YOOJIN | - |
dc.contributor.affiliatedAuthor | KIM, BYEANG HYEAN | - |
dc.identifier.scopusid | 2-s2.0-85038836122 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | ARTICLE | - |
dc.subject.keywordPlus | DNA APTAMER | - |
dc.subject.keywordPlus | FLUORESCENT BIOSENSOR | - |
dc.subject.keywordPlus | DISPLACEMENT | - |
dc.subject.keywordPlus | STRATEGY | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordAuthor | Quencher-free molecular aptamer beacon | - |
dc.subject.keywordAuthor | Aptamer molecular beacon | - |
dc.subject.keywordAuthor | Quecher-free molecular beacon | - |
dc.subject.keywordAuthor | ATP-binding aptamer | - |
dc.subject.keywordAuthor | Fluorescence sensor | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
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