The role of RNA helicases in aging and lifespan regulation
SCOPUS
- Title
- The role of RNA helicases in aging and lifespan regulation
- Authors
- Sangsoon Park; Park, Hae-Eun H.; Son, Heehwa G.; Lee, Seung-Jae V.
- Date Issued
- 2017-10
- Publisher
- KeAi Publishing Communications
- Abstract
- RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between
RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA export, nonsensemediated
mRNA decay, and telomere maintenance. In this review, we discuss the recent discoveries on several RNA helicases that play key
roles in aging and lifespan regulation. We first describe the roles of several mammalian RNA helicases implicated in cellular senescence. In
addition, we discuss our previous reports showing that three RNA helicases, HEL-1/DDX39, SACY-1/DDX41 and SMG-2/UPF1, promote
longevity in Caenorhabditis elegans through distinct mechanisms. These findings reveal the critical functions of many RNA helicases in
regulating aging and may lead to insights into the importance of RNA homeostasis in aging and longevity.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/41056
- DOI
- 10.1016/j.tma.2017.08.001
- ISSN
- 2468-5011
- Article Type
- Article
- Citation
- Translational Medicine of Aging, vol. 1, page. 24 - 31, 2017-10
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.