DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jinkyung Kim | - |
dc.contributor.author | Namseop Kwon | - |
dc.contributor.author | Soeun Chang | - |
dc.contributor.author | KIM, KYONG TAI | - |
dc.contributor.author | Dongmyeong Lee | - |
dc.contributor.author | KIM, SEUNGHWAN | - |
dc.contributor.author | So Jeong Yun | - |
dc.contributor.author | HWANG, DAEHEE | - |
dc.contributor.author | Jee Woong Kim | - |
dc.contributor.author | Yeukuang Hwu | - |
dc.contributor.author | Giorgio Margaritondo | - |
dc.contributor.author | JE, JUNG HO | - |
dc.contributor.author | Im Joo Rhyu | - |
dc.date.accessioned | 2018-05-04T02:49:18Z | - |
dc.date.available | 2018-05-04T02:49:18Z | - |
dc.date.created | 2018-03-18 | - |
dc.date.issued | 2011-10-18 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/41371 | - |
dc.description.abstract | Disrupted cortical cytoarchitecture in cerebellum is a typical pathology in reeler. Particularly interesting are structural problems at the cellular level: dendritic morphology has important functional implication in signal processing. Here we describe a combinatorial imaging method of synchrotron X-ray microtomography with Golgi staining, which can deliver 3-dimensional(3-D) micro-architectures of Purkinje cell(PC) dendrites, and give access to quantitative information in 3-D geometry. In reeler, we visualized in 3-D geometry the shape alterations of planar PC dendrites (i.e., abnormal 3-D arborization). Despite these alterations, the 3-D quantitative analysis of the branching patterns showed no significant changes of the 77 +/- 8 degrees branch angle, whereas the branch segment length strongly increased with large fluctuations, comparing to control. The 3-D fractal dimension of the PCs decreased from 1.723 to 1.254, indicating a significant reduction of dendritic complexity. This study provides insights into etiologies and further potential treatment options for lissencephaly and various neurodevelopmental disorders. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.title | Altered branching patterns of Purkinje cells in mouse model for cortical development disorder | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/SREP00122 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.1, pp.122 | - |
dc.identifier.wosid | 000296056400002 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.startPage | 122 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 1 | - |
dc.contributor.affiliatedAuthor | KIM, KYONG TAI | - |
dc.contributor.affiliatedAuthor | KIM, SEUNGHWAN | - |
dc.contributor.affiliatedAuthor | HWANG, DAEHEE | - |
dc.contributor.affiliatedAuthor | JE, JUNG HO | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | REELER MUTANT MOUSE | - |
dc.subject.keywordPlus | X-RAYS | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | NEURONAL MIGRATION | - |
dc.subject.keywordPlus | CEREBELLUM | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | RADIOLOGY | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | COMPLEXITY | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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