간 경변증 치료를 위한 3차원 세포 프린팅 기반의 중간엽줄기세포가 봉입된 패치 형태 치료제 개발
- Title
- 간 경변증 치료를 위한 3차원 세포 프린팅 기반의 중간엽줄기세포가 봉입된 패치 형태 치료제 개발
- Authors
- WONIL, HAN; Jung-Hee Kim; HYUNGSEOK, LEE; Dong Jun Park; Eun Byul Lee; JANG, JINAH; Seung Kew Yoon; CHO, DONG WOO
- Date Issued
- 2017-12-14
- Publisher
- 한국정밀공학회
- Abstract
- Liver cirrhosis is an irreversible end-stage liver disease which has no effective therapy except for liver transplantation, but donor
shortage has been a critical limitation. Stem cell injection has been regarded as an alternative therapy to the liver transplantation; yet,
there is no optimal condition for such therapy. Moreover, the efficiency of delivery is below 10%, and the efficacy is reported to be
minimal or even none. Therefore, we developed a new stem cell delivery method, which is a 3D cell printed patch-type stem cell
therapy (liver patch) with liver decellularized extracellular matrix (LdECM) bioink and human bone marrow derived mesenchymal
stem cell to enhance the efficacy and delivery efficiency. The liver patch showed in vitro efficacy in the inactivation of the activated
hepatic stellate cell (aHSC) by paracrine effect in transwell coculture condition. For in vivo efficacy assessment, the liver patch was
implanted to the pathological liver tissue of irreversible cirrhosis mouse models. The deposited endogenous collagen was significantly
decreased, and aHSCs were inactivated in the liver patch delivered cirrhosis model. Consequently, the results demonstrated that the
liver patch with functional LdECM bioink and stem cell would be an effective therapy for liver cirrhosis treatment.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/41655
- Article Type
- Conference
- Citation
- 한국정밀공학회 2017 추계학술대회, page. 70 - 70, 2017-12-14
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.