DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Donghyun | - |
dc.contributor.author | Lee, Changho | - |
dc.contributor.author | Kwon, Woosung | - |
dc.contributor.author | Beack, Songeun | - |
dc.contributor.author | KIM, CHULHONG | - |
dc.date.accessioned | 2018-05-10T23:04:18Z | - |
dc.date.available | 2018-05-10T23:04:18Z | - |
dc.date.created | 2018-02-14 | - |
dc.date.issued | 2017-01-30 | - |
dc.identifier.issn | 0277-786X | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/42430 | - |
dc.description.abstract | We synthesized nitrogen-doped carbon nanodots (N-CNDs) for photoacoustic (PA) imaging and photothermal therapy (PTT) by controlling the nitrogen source and carbonizing organic acids. The N-CNDs showed strong optical absorbance in the near-infrared region, with great photostability and biodegradability. Thanks to the strong optical absorbance of N-CNDs, the PA signals from N-CNDs were high enough to detect inside living animals and enabled minimally invasive PTT using N-CND. To evaluate the biodegradability and potential application of N-CNDs as a PA imaging contrast agent, we performed time-resolved PA imaging of sentinel lymph nodes (SLNs) and assessed renal clearance after hypodermic injection. SLN and vascular networks were photoacoustically visualized by an acoustic-resolution reflection-mode PA imaging system at a 680-nm optical wavelength. Furthermore, we performed whole-body PA imaging after subcutaneous injection of N-CNDs to assess their body distribution and clearance. Finally, we further investigated the use of N-CNDs for in vivo photothermal therapy in Balb/c nude xenograft HepG2-tumor model mice. | - |
dc.language | English | - |
dc.publisher | SPIE | - |
dc.relation.isPartOf | Conference on Photons Plus Ultrasound - Imaging and Sensing | - |
dc.relation.isPartOf | PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017 | - |
dc.title | N-doped carbon nanodots for non-invasive photoacoustic imaging and photothermal therapy | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.identifier.bibliographicCitation | Conference on Photons Plus Ultrasound - Imaging and Sensing | - |
dc.citation.conferenceDate | 2017-01-29 | - |
dc.citation.conferencePlace | US | - |
dc.citation.title | Conference on Photons Plus Ultrasound - Imaging and Sensing | - |
dc.contributor.affiliatedAuthor | KIM, CHULHONG | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
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