Transcription of D site of Albumin promoter binding protein(Dbp) is controlled by a position-dependent motif sequence

Abstract

Circadian rhythm depends on transcriptional regulation of clock controlled genes. Several transcriptional regulations have been identified and their contribution to circadian rhythm has been assessed. However, there are mostly focusing on well-known clock-controlled genes solely. Although Dbp (D Site of Albumin Promoter Binding protein) shows strong rhythmicity gene, transcriptional regulation of Dbp still remains little knowledge. Here, we elucidated an in-depth molecular mechanism that is involved in the transcriptional regulation of Dbp. Additionally, we identified a new role of the position effect of CT motif which can foster Dbp transcription either down regulate of transcription depending on the position from transcription start site. Here, we propose a model whrereby CT motif of Dbp plays a role in transcription modulated by position dependent manners.