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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 류혜국 | - |
| dc.contributor.author | MYUNG, SU KANG | - |
| dc.contributor.author | CHOI TEAYONG | - |
| dc.contributor.author | 이도현 | - |
| dc.contributor.author | 이승현 | - |
| dc.contributor.author | 최세영 | - |
| dc.contributor.author | KIM, KYONG TAI | - |
| dc.date.accessioned | 2018-05-11T00:44:36Z | - |
| dc.date.available | 2018-05-11T00:44:36Z | - |
| dc.date.created | 2018-03-02 | - |
| dc.date.issued | 2017-08-30 | - |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/42914 | - |
| dc.description.abstract | Vaccinia-relatedkinases(VRKs)aremultifacetedserine/threoninekinasesthatplayessentialrolesinvariousaspectsofcellsignaling,cellcycleprogression,apoptosis,andneuronaldevelopmentanddifferentiation.However,theneuronalfunctionofVRK3isstillunknowninspiteofitsetiologicalpotentialinhumanautismspectrumdisorder(ASD).Here,wereportthatVRK3-deficientmiceexhibitedtypicalsymptomsofautism-likebehaviorincludinghyperactivity,stereotypedbehaviors,reducedsocialinteraction,andimpairedcontextdependentspatialmemory.SignificantdecreaseindendriticspinenumberandarborizationwereidentifiedinthehippocampusCA1ofVRK3-deficientmice.ThesemicealsoexhibitedareducedrectificationofAMPAreceptor-mediatedcurrentandchangesinexpressionofsynapticandsignalingproteinsincludingTrkB,ArcandCaMKIIα.Notably,TrkBstimulationwith7,8-dihydroxyflavone(7,8-DHF)reversedthealteredsynapticstructureandfunction,andsuccessfullyrestoredautism-likebehaviorinVRK3-deficientmice.TheseresultsrevealthatVRK3playsacriticalroleinneurodevelopmentaldisordersandsuggestapotentialtherapeuticstrategyforASD. | - |
| dc.publisher | KSBNS | - |
| dc.relation.isPartOf | The 20th Annual Meeting of the Korean Society Brain and Neural Science Co-organized by the Korean Society for Neurodegenerative Disease | - |
| dc.relation.isPartOf | Challenge the Brain Change the Future | - |
| dc.title | Autism-Like Behavior Caused by Deletion of Vaccinia-related Kinase 3 is Improved by TrkBStimulation | - |
| dc.type | Conference | - |
| dc.type.rims | CONF | - |
| dc.identifier.bibliographicCitation | The 20th Annual Meeting of the Korean Society Brain and Neural Science Co-organized by the Korean Society for Neurodegenerative Disease | - |
| dc.citation.conferenceDate | 2017-08-30 | - |
| dc.citation.conferencePlace | KO | - |
| dc.citation.conferencePlace | Grand Hilton, Seoul | - |
| dc.citation.title | The 20th Annual Meeting of the Korean Society Brain and Neural Science Co-organized by the Korean Society for Neurodegenerative Disease | - |
| dc.contributor.affiliatedAuthor | 류혜국 | - |
| dc.contributor.affiliatedAuthor | MYUNG, SU KANG | - |
| dc.contributor.affiliatedAuthor | 이도현 | - |
| dc.contributor.affiliatedAuthor | KIM, KYONG TAI | - |
| dc.description.journalClass | 2 | - |
| dc.description.journalClass | 2 | - |
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- 김경태KIM, KYONG TAI
- Dept of Life Sciences