DAP5 promotes axonal outgrowth by increasing the translation of DSCR1.4
- Title
- DAP5 promotes axonal outgrowth by increasing the translation of DSCR1.4
- Authors
- JI, YOUNG SEO; Do-Yeon Kim; HYE, GUK RYU; KIM, HYOJIN; YOUNGSEOB, JUNG; KIM, KYONG TAI
- Date Issued
- 2017-05-18
- Publisher
- KSBMB
- Abstract
- Spatial and temporal regulation of protein synthesis in
axon is important for axon outgrowth and steering.
Down syndrome candidate region 1(DSCR1)
regulates actin filaments formation and local
translation in axon by controling calcineurin,
phospatase. However, it is unknown whether DSCR1
mRNA is locally translated in axon. Here, we
investigated that DSCR1.4 mRNA, one of DSCR1
isoform exist and is translated in both soma and axon.
Not only cap-dependent but also cap-independent
translation is important for DSCR1.4 protein
synthesis. Translation of DSCR1.4 mRNA is
increased by Death-associated protein 5 (DAP5).
DSCR1.4 increased by DAP5 makes axons longer.
These findings have implications for understanding
relation of local translation and axon outgrowth,
steering.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/43117
- Article Type
- Conference
- Citation
- KSBMB International Conference 2017, 2017-05-18
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