DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, J | - |
dc.contributor.author | Li, Q | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.contributor.author | Kim, TS | - |
dc.date.accessioned | 2018-06-15T05:09:59Z | - |
dc.date.available | 2018-06-15T05:09:59Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2005-04 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50157 | - |
dc.description.abstract | Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4(+) T cells, is an important stimulus for the switch of the antibody isotype to IgE in both mice and humans. In this study we investigated the inhibitory activity of IL-4 production in activated T cells by screening ceramide derivatives prepared by solid phase combinatorial chemistry. Many ceramide derivatives significantly inhibited IL-4 production in T cells. In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents. (c) 2005 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.subject | TRANSCRIPTION FACTOR GATA-3 | - |
dc.subject | HUMAN IL-4 PROMOTER | - |
dc.subject | IMMUNE-RESPONSE | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | NUCLEAR FACTOR | - |
dc.subject | HL-60 CELLS | - |
dc.subject | TH2 CELLS | - |
dc.subject | B-CELLS | - |
dc.subject | NF-ATC | - |
dc.subject | EXPRESSION | - |
dc.title | Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bmc.2005.01.027 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.13, no.7, pp.2589 - 2595 | - |
dc.identifier.wosid | 000227891000024 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 2595 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2589 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-14844309752 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR GATA-3 | - |
dc.subject.keywordPlus | HUMAN IL-4 PROMOTER | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | NUCLEAR FACTOR | - |
dc.subject.keywordPlus | HL-60 CELLS | - |
dc.subject.keywordPlus | TH2 CELLS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | NF-ATC | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | ceramide library | - |
dc.subject.keywordAuthor | interleukin-4 | - |
dc.subject.keywordAuthor | T cells | - |
dc.subject.keywordAuthor | allergy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
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