Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceram ides
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SCOPUS
- Title
- Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceram ides
- Authors
- Yu, KOA; Im, JS; Molano, A; Dutronc, Y; Illarionov, PA; Forestier, C; Fujiwara, N; Arias, I; Miyake, S; Yamamura, T; Chang, Young-Tae; Besra, GS; Porcelli, SA
- Date Issued
- 2005-03
- Publisher
- NATL ACAD SCIENCES
- Abstract
- A form of alpha-galactosylceramide, KRN7000, activates CD1d-restricted Valpha14-invariant (Valpha14i) natural killer (NK) T cells and initiates multiple downstream immune reactions. We report that substituting the C26:0 N-acyl chain of KRN7000 with shorter, unsaturated fatty acids modifies the outcome of Valpha14i NKT cell activation. One analogue containing a diunsaturated C20 fatty acid (C20:2) potently induced a T helper type 2-biased cytokine response, with diminished IFN-gamma production and reduced Valpha14i NKT cell expansion. C20:2 also exhibited less stringent requirements for loading onto CD1d than KRN7000, suggesting a mechanism for the immunomodulatory properties of this lipid. The differential cellular response elicited by this class of Valpha14i NKT cell agonists may prove to be useful in immunotherapeutic applications.
- Keywords
- KILLER T-CELLS; IL-4 PRODUCTION; AUTOIMMUNE ENCEPHALOMYELITIS; GLYCOLIPID ANTIGENS; CD1D MOLECULES; IFN-GAMMA; MOUSE CD1; NOD MICE; PREVENTS; ACTIVATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50158
- DOI
- 10.1073/pnas.0407488102
- ISSN
- 0027-8424
- Article Type
- Article
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 9, page. 3383 - 3388, 2005-03
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