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Cited 62 time in webofscience Cited 71 time in scopus
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Tools for target identification and validation SCIE SCOPUS

Title
Tools for target identification and validation
Authors
Wang, SLSim, TBChang, Young-Tae
Date Issued
2004-08
Publisher
CURRENT BIOLOGY LTD
Abstract
Reliable technologies for addressing target identification and validation are the foundation of successful drug development. Microarrays have been well utilized in genomics/proteomics approaches for gene/protein expression profiling and tissue/ cell-scale target validation. Besides being used as an essential step in analyzing high-throughput experiments such as those involving microarrays, bioinformatics can also contribute to the processes of target identification and validation by providing functional information about target candidates and positioning information to biological networks. Antisense technologies (including RNA interference technology, which is recently very 'hot') enable sequence-based gene knockdown at the RNA level. Zinc finger proteins are a DNA transcription-targeting version of knockdown. Chemical genomics and proteomics are emerging tools for generating phenotype changes, thus leading to target and hit identifications. NMR-based screening, as well as activity-based protein profiling, are trying to meet the requirement of high-throughput target identification.
Keywords
RNA INTERFERENCE; DRUG DISCOVERY; PROTEIN MICROARRAYS; GENE-EXPRESSION; IN-SILICO; CANCER; TECHNOLOGIES; PERSPECTIVE; MUTAGENESIS; SEQUENCE
URI
https://oasis.postech.ac.kr/handle/2014.oak/50165
DOI
10.1016/j.cbpa.2004.06.001
ISSN
1367-5931
Article Type
Article
Citation
CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 8, no. 4, page. 371 - 377, 2004-08
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