The combinatorial synthesis of purine, pyrimidine and triazinebased libraries

Abstract

With the advent of combinatorial chemistry, heterocyclic scaffolds can be efficiently used for the generation of large member libraries. Due to the pressing need for such compound libraries, unique synthesis reactions and techniques have been developed to expedite and further improve the process. Present review article summarizes synthetic strategies for the construction of purine, pyrimidine and triazine libraries in both solution and solid phase syntheses. Typical strategy includes the nucleophilc aromatic substitution, such as amination. Also, metal-mediated synthesis has been used as a driving tool in expanding the diversity of the libraries. Demonstrated biological properties of these libraries, as a rich source of bioactivities, are also highlighted.