DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bricard, Gabriel | - |
dc.contributor.author | Venkataswamy, Manjunatha M. | - |
dc.contributor.author | Yu, Karl O. A. | - |
dc.contributor.author | Im, Jin S. | - |
dc.contributor.author | Ndonye, Rachel M. | - |
dc.contributor.author | Howell, Amy R. | - |
dc.contributor.author | Veerapen, Natacha | - |
dc.contributor.author | Illarionov, Petr A. | - |
dc.contributor.author | Besra, Gurdyal S. | - |
dc.contributor.author | Li, Qian | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.contributor.author | Porcelli, Steven A. | - |
dc.date.accessioned | 2018-06-15T05:12:51Z | - |
dc.date.available | 2018-06-15T05:12:51Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50214 | - |
dc.description.abstract | CD1d-restricted natural killer T cells with invariant T cell receptor alpha chains (iNKT cells) are a unique lymphocyte subset that responds to recognition of specific lipid and glycolipid antigens. They are conserved between mice and humans and exert various immunoregulatory functions through their rapid secretion of a variety of cytokines and secondary activation of dendritic cells, B cells and NK cells. In the current study, we analyzed the range of functional activation states of human iNKT cells using a library of novel analogs of alpha-galactosylceramide (alpha GalCer), the prototypical iNKT cell antigen. Measurement of cytokines secreted by human iNKT cell clones over a wide range of glycolipid concentrations revealed that iNKT cell ligands could be classified into functional groups, correlating with weak versus strong agonistic activity. The findings established a hierarchy for induction of different cytokines, with thresholds for secretion being consistently lowest for IL-13, higher for interferon-gamma (IFN gamma), and even higher for IL-4. These findings suggested that human iNKT cells can be intrinsically polarized to selective production of IL-13 by maintaining a low level of activation using weak agonists, whereas selective polarization to IL-4 production cannot be achieved through modulating the strength of the activating ligand. In addition, using a newly designed in vitro system to assess the ability of human iNKT cells to transactivate NK cells, we found that robust secondary induction of interferon-gamma secretion by NK cells was associated with strong but not weak agonist ligands of iNKT cells. These results indicate that polarization of human iNKT cell responses to Th2-like or anti-inflammatory effects may best be achieved through selective induction of IL-13 and suggest potential discrepancies with findings from mouse models that may be important in designing iNKT cell-based therapies in humans. | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.subject | KILLER T-CELLS | - |
dc.subject | INVARIANT NKT CELLS | - |
dc.subject | CD1D MOLECULES | - |
dc.subject | TUMOR IMMUNOSURVEILLANCE | - |
dc.subject | ANTITUMOR CYTOTOXICITY | - |
dc.subject | CUTTING EDGE | - |
dc.subject | NOD MICE | - |
dc.subject | ACTIVATION | - |
dc.subject | RECOGNITION | - |
dc.subject | ANTIGENS | - |
dc.title | alpha-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0014374 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.5, no.12 | - |
dc.identifier.wosid | 000285572900008 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.number | 12 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-78650782254 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | KILLER T-CELLS | - |
dc.subject.keywordPlus | INVARIANT NKT CELLS | - |
dc.subject.keywordPlus | CD1D MOLECULES | - |
dc.subject.keywordPlus | TUMOR IMMUNOSURVEILLANCE | - |
dc.subject.keywordPlus | ANTITUMOR CYTOTOXICITY | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | NOD MICE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | ANTIGENS | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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