DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, Jin S. | - |
dc.contributor.author | Arora, Pooja | - |
dc.contributor.author | Bricard, Gabriel | - |
dc.contributor.author | Molano, Alberto | - |
dc.contributor.author | Venkataswamy, Manjunatha M. | - |
dc.contributor.author | Baine, Ian | - |
dc.contributor.author | Jerud, Elliot S. | - |
dc.contributor.author | Goldberg, Michael F. | - |
dc.contributor.author | Baena, Andres | - |
dc.contributor.author | Yu, Karl O. A. | - |
dc.contributor.author | Ndonye, Rachel M. | - |
dc.contributor.author | Howell, Amy R. | - |
dc.contributor.author | Yuan, Weiming | - |
dc.contributor.author | Cresswell, Peter | - |
dc.contributor.author | Chang, Young-tae | - |
dc.contributor.author | Illarionov, Petr A. | - |
dc.contributor.author | Besra, Gurdyal S. | - |
dc.contributor.author | Porcelli, Steven A. | - |
dc.date.accessioned | 2018-06-15T05:13:47Z | - |
dc.date.available | 2018-06-15T05:13:47Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2009-06 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50235 | - |
dc.description.abstract | CID1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating a galactosylceramide (alpha GalCer) analogs that give predominantly Th2 cell-type cytokine responses to determine how ligand structure controls the outcome of NKT cell activation. Using a monoclonal antibody specific for alpha GalCer-CD1d complexes to visualize and quantitate glycolipid presentation, we found that Th2 cell-type cytokine-biasing ligands were characterized by rapid and direct loading of cell-surface CD1d proteins. Complexes formed by association of these Th2 cell-type cytokine-biasing alpha GalCer analogs with CD1d showed a distinctive exclusion from ganglioside-enriched, detergent-resistant plasma membrane microdomains of antigen-presenting cells. These findings help to explain how subtle alterations in glycolipid ligand structure can control the balance of proinflammatory and anti-inflammatory activities of NKT cells. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | IMMUNITY | - |
dc.subject | HUMAN CD1D MOLECULES | - |
dc.subject | LIGAND ALPHA-GALACTOSYLCERAMIDE | - |
dc.subject | II-PEPTIDE COMPLEXES | - |
dc.subject | NKT CELLS | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | LIPID RAFTS | - |
dc.subject | IN-VIVO | - |
dc.subject | RECOGNITION | - |
dc.subject | PROTEINS | - |
dc.title | Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.immuni.2009.03.022 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IMMUNITY, v.30, no.6, pp.888 - 898 | - |
dc.identifier.wosid | 000267270700015 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 898 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 888 | - |
dc.citation.title | IMMUNITY | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Chang, Young-tae | - |
dc.identifier.scopusid | 2-s2.0-66949155720 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 119 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HUMAN CD1D MOLECULES | - |
dc.subject.keywordPlus | LIGAND ALPHA-GALACTOSYLCERAMIDE | - |
dc.subject.keywordPlus | II-PEPTIDE COMPLEXES | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | LIPID RAFTS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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