Selective human serum albumin sensor from the screening of a fluorescent rosamine library
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SCOPUS
- Title
- Selective human serum albumin sensor from the screening of a fluorescent rosamine library
- Authors
- Ahn, Young-Hoon; Lee, Jun-Seok; Chang, Young-Tae
- Date Issued
- 2008-05
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A fluorescent dye library approach for the development of a bioanalyte sensor was sought. The screening of a rosamine dye library against diverse macromolecules led to the discovery of a highly sensitive human serum albumin binder, G13, with similar to 36-fold fluorescence intensity change. G13 showed a highly selective response to HSA over other macromolecules including albumins from other species. The potential use of G13 for the detection of HSA in biofluids is described.
- Keywords
- DRUG-BINDING-SITES; CRYSTAL-STRUCTURE; PROBE; MICROALBUMINURIA; PLATFORM; ACIDS; DYES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50242
- DOI
- 10.1021/cc800017h
- ISSN
- 1520-4766
- Article Type
- Article
- Citation
- JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 10, no. 3, page. 376 - 380, 2008-05
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