Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents
SCIE
SCOPUS
- Title
- Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents
- Authors
- Zhou, Chunhui; Min, Jaeki; Liu, Zhigang; Young, Anne; Deshazer, Heather; Gao, Tian; Chang, Young-Tae; Kallenbach, Neville R.
- Date Issued
- 2008-02
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity. (c) 2008 Elsevier Ltd. All rights reserved.
- Keywords
- CATIONIC ANTIBACTERIAL PEPTIDES; LIBRARIES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50246
- DOI
- 10.1016/j.bmcl.2008.01.031
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 4, page. 1308 - 1311, 2008-02
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- There are no files associated with this item.
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