DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dong Soo | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Song, Ju Han | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.contributor.author | Hwang, Seung Yong | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2018-06-15T05:14:21Z | - |
dc.date.available | 2018-06-15T05:14:21Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50247 | - |
dc.description.abstract | Differentiation-inducing therapy by agents such as 1,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3] represents a useful approach for the treatment for cancer, including acute myeloid leukemia (AML). Recent studies demonstrated that the combined administration of 1,25-(OH)(2)D-3 and differentiation-enhancing agents could alleviate the side effects of 1,25-(OH)(2)D-3 and improve the rate of long term survival. In this study, we determined the enhancing activities of ceramide derivatives on 1,25-(OH)(2)D-3-induced differentiation of human myeloid leukemia HL-60 cells. Importantly, some of these derivatives-namely, A2, B3, and H9-enhanced the 1,25-(OH)(2)D-3-induced differentiation of HL-60 cells in a concentration-dependent manner. In addition, the morphologic studies using Giemsa staining and flow cytometric analysis demonstrated that the combined treatment of 1,25-(OH)(2)D-3 with one of the three analogues, A2, B3, and H9, directed the HL-60 cells into monocytic lineage, but not into granulocytic lineage. The inhibition studies demonstrated that A2, B3, and H9, enhanced 1,25-(OH)(2)D-3-induced differentiation of HL-60 cells via the PI3-K/PKC/JNK/ERK pathways. The ability of ceramide derivatives to enhance the differentiation-inducing potential of 1,25-(OH)(2)D-3 may contribute to an effective therapy for AML. (C) 2007 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | LIFE SCIENCES | - |
dc.subject | ACID-INDUCED DIFFERENTIATION | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | RETINOIC ACID | - |
dc.subject | INDUCE DIFFERENTIATION | - |
dc.subject | SESQUITERPENE LACTONE | - |
dc.subject | MULTIDRUG-RESISTANCE | - |
dc.subject | SODIUM-BUTYRATE | - |
dc.subject | HL60 CELLS | - |
dc.subject | T-CELLS | - |
dc.subject | D-3 | - |
dc.title | Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D-3-induced differentiation of human HL-60 leukemia cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.lfs.2007.09.035 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.81, no.25-26, pp.1638 - 1644 | - |
dc.identifier.wosid | 000251990200002 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1644 | - |
dc.citation.number | 25-26 | - |
dc.citation.startPage | 1638 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 81 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-36448975827 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 16 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACID-INDUCED DIFFERENTIATION | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | INDUCE DIFFERENTIATION | - |
dc.subject.keywordPlus | SESQUITERPENE LACTONE | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | SODIUM-BUTYRATE | - |
dc.subject.keywordPlus | HL60 CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | D-3 | - |
dc.subject.keywordAuthor | ceramide library | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | leukemia | - |
dc.subject.keywordAuthor | 1,25-dihydroxyvitamin D-3 | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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