Tagged library approach facilitates forward chemical genetics
SCIE
SCOPUS
- Title
- Tagged library approach facilitates forward chemical genetics
- Authors
- Kim, Yun Kyung; Chang, Young-Tae
- Date Issued
- 2007
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- Forward chemical genetics has been highlighted as a new method for the study of various biological pathways using exogenous ligands. However, limited success in the field has demonstrated that, in many cases, it is not feasible to determine the protein targets of small-molecule probes. Identifying protein targets is an integral part of forward chemical genetics and is also the most challenging. Over the past decade, several biochemical and genetic methods have been developed to facilitate target identification processes. Even so, one of the major difficulties is that these methods require the chemical modification of active compounds, with a significant amount of structure-activity relationship (SAR) study to ensure that the small-molecule tags do not compromise bioactivity. In this article, we will highlight a new strategy for small molecule libraries that have built-in linkers in order to avoid this well-known problem and demonstrate their successful use in forward chemical genetics.
- Keywords
- MAMMALIAN HISTONE DEACETYLASE; SMALL MOLECULES; TRIAZINE LIBRARY; CAENORHABDITIS-ELEGANS; TARGET IDENTIFICATION; CYCLIC TETRAPEPTIDE; 3-HYBRID APPROACH; INHIBITORS; CHEMISTRY; GENOMICS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50260
- DOI
- 10.1039/b702321a
- ISSN
- 1742-206X
- Article Type
- Article
- Citation
- MOLECULAR BIOSYSTEMS, vol. 3, no. 6, page. 392 - 397, 2007
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.