Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking
SCIE
SCOPUS
- Title
- Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking
- Authors
- Haque, Md. Mamunul; Kim, Dohee; Yu, Young Hyun; Lim, Sungsu; Kim, Dong Jin; Chang, Young-Tae; Ha, Hyung-Ho; Kim, Yun Kyung
- Date Issued
- 2014-09
- Publisher
- INFORMA HEALTHCARE
- Abstract
- Abnormal tau aggregates are presumed to be neurotoxic and are an important therapeutic target for multiple neurodegenerative disorders including Alzheimer's disease. Growing evidence has shown that tau intermolecular disulfide cross-linking is critical in generating tau oligomers that serve as a building block for higher-order aggregates. Here we report that a small molecule inhibitor prevents tau aggregation by blocking the generation of disulfide cross-linked tau oligomers. Among the compounds tested, a rosamine derivative bearing mild thiol reactivity selectively labeled tau and effectively inhibited oligomerization and fibrillization processes in vitro. Our data suggest that controlling tau oxidation status could be a new therapeutic strategy for prevention of abnormal tau aggregation.
- Keywords
- PAIRED HELICAL FILAMENTS; ALZHEIMERS-DISEASE; IN-VITRO; PROTEIN-TAU; OLIGOMERS; CELLS; BETA(2)-MICROGLOBULIN; NEURODEGENERATION; TAUOPATHIES; OXIDATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50289
- DOI
- 10.3109/13506129.2014.929103
- ISSN
- 1350-6129
- Article Type
- Article
- Citation
- AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, vol. 21, no. 3, page. 185 - 190, 2014-09
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