DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hirata, Nao | - |
dc.contributor.author | Nakagawa, Masato | - |
dc.contributor.author | Fujibayashi, Yuto | - |
dc.contributor.author | Yamauchi, Kaori | - |
dc.contributor.author | Murata, Asako | - |
dc.contributor.author | Minami, Itsunari | - |
dc.contributor.author | Tomioka, Maiko | - |
dc.contributor.author | Kondo, Takayuki | - |
dc.contributor.author | Kuo, Ting-Fang | - |
dc.contributor.author | Endo, Hiroshi | - |
dc.contributor.author | Inoue, Haruhisa | - |
dc.contributor.author | Sato, Shin-ichi | - |
dc.contributor.author | Ando, Shin | - |
dc.contributor.author | Kawazoe, Yoshinori | - |
dc.contributor.author | Aiba, Kazuhiro | - |
dc.contributor.author | Nagata, Koh | - |
dc.contributor.author | Kawase, Eihachiro | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.contributor.author | Suemori, Hirofumi | - |
dc.contributor.author | Eto, Koji | - |
dc.contributor.author | Nakauchi, Hiromitsu | - |
dc.contributor.author | Yamanaka, Shinya | - |
dc.contributor.author | Nakatsuji, Norio | - |
dc.contributor.author | Ueda, Kazumitsu | - |
dc.contributor.author | Uesugi, Motonari | - |
dc.date.accessioned | 2018-06-15T05:16:51Z | - |
dc.date.available | 2018-06-15T05:16:51Z | - |
dc.date.created | 2017-09-08 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50297 | - |
dc.description.abstract | A small-molecule fluorescent probe specific for human pluripotent stem cells would serve as a useful tool for basic cell biology research and stem cell therapy. Screening of fluorescent chemical libraries with human induced pluripotent stem cells (iPSCs) and subsequent evaluation of hit molecules identified a fluorescent compound (Kyoto probe 1 [KP-1]) that selectively labels human pluripotent stem cells. Our analyses indicated that the selectivity results primarily from a distinct expression pattern of ABC transporters in human pluripotent stem cells and from the transporter selectivity of KP-1. Expression of ABCB1 (MDR1) and ABCG2 (BCRP), both of which cause the efflux of KP-1, is repressed in human pluripotent stem cells. Although KP-1, like other pluripotent markers, is not absolutely specific for pluripotent stem cells, the identified chemical probe may be used in conjunction with other reagents. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.subject | FUNCTIONAL EXPRESSION | - |
dc.subject | MULTIDRUG TRANSPORTER | - |
dc.subject | HUMAN FIBROBLASTS | - |
dc.subject | ABC TRANSPORTERS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | SMALL-MOLECULE | - |
dc.subject | GERM-CELLS | - |
dc.subject | IN-VITRO | - |
dc.subject | ES CELLS | - |
dc.subject | DIFFERENTIATION | - |
dc.title | A Chemical Probe that Labels Human Pluripotent Stem Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.celrep.2014.02.006 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.6, no.6, pp.1165 - 1174 | - |
dc.identifier.wosid | 000333465000020 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1174 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1165 | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Chang, Young-Tae | - |
dc.identifier.scopusid | 2-s2.0-84897101263 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 25 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FUNCTIONAL EXPRESSION | - |
dc.subject.keywordPlus | MULTIDRUG TRANSPORTER | - |
dc.subject.keywordPlus | HUMAN FIBROBLASTS | - |
dc.subject.keywordPlus | ABC TRANSPORTERS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | SMALL-MOLECULE | - |
dc.subject.keywordPlus | GERM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ES CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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