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Visualization and Isolation of Langerhans Islets by a Fluorescent Probe PiY SCIE SCOPUS
- Title
- Visualization and Isolation of Langerhans Islets by a Fluorescent Probe PiY
- Authors
- Kang, Nam-Young; Lee, Sung-Chan; Park, Sung-Jin; Ha, Hyung-Ho; Yun, Seong-Wook; Kostromina, Elena; Gustavsson, Natalia; Ali, Yusuf; Chandran, Yogeswari; Chun, Hang-Suk; Bae, MyungAe; Ahn, Jin Hee; Han, Weiping; Radda, George K.; Chang, Young-Tae
- Date Issued
- 2013-08
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A pancreatic beta cell selective probe PiY (red, see picture) was developed which stains Langerhans islets in live animals without toxicity or side effects. Through tail-vein injection, PiY allowed for a comparison of the islets between healthy and diabetic mice. PiY also facilitated the isolation of healthy Langerhans islets by using a fluorescence-guided surgical procedure.
- Keywords
- INSULIN-SECRETION; PANCREATIC-ISLETS; BETA-CELLS; PROTEINS; BINDING
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 52, no. 33, page. 8557 - 8560, 2013-08
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Related Researcher
- 장영태CHANG, YOUNG TAE
- Dept of Chemistry