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Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach SCIE SCOPUS
- Title
- Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach
- Authors
- Zhang, Liyun; Er, Jun Cheng; Li, Xin; Heng, Jie; Samanta, Animesh; Chang, Young-Tae; Lee, Chi-Lik Ken
- Date Issued
- 2015-03
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- A 241-membered cyanine-based library was constructed by the combinatorial chemistry strategy. Combined with high-throughput screening, we successfully discovered a novel fluorescent probe (CyC-M716) capable of identifying a subset of parallel G-quadruplexes with propeller loops stretching across three tetrad layers with high sensitivity and selectivity.
- ISSN
- 1359-7345
- Article Type
- Article
- Citation
- CHEMICAL COMMUNICATIONS, vol. 51, no. 34, page. 7386 - 7389, 2015-03
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Related Researcher
- 장영태CHANG, YOUNG TAE
- Dept of Chemistry