DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, O. | - |
dc.contributor.author | Kwak, D. | - |
dc.contributor.author | Ha, S.H. | - |
dc.contributor.author | Jeon, H. | - |
dc.contributor.author | Park, M. | - |
dc.contributor.author | Chang, Y. | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, S.H. | - |
dc.date.accessioned | 2018-06-15T05:23:06Z | - |
dc.date.available | 2018-06-15T05:23:06Z | - |
dc.date.created | 2017-12-05 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50419 | - |
dc.description.abstract | Lysosomal localization of mammalian target of rapamycin complex 1 (mTORC1) is a critical step for activation of the molecule. Rag GTPases are essential for this translocation. Here, we demonstrate that Nudix-type motif 2 (NUDT2) is a novel positive regulator of mTORC1 activation. Activation of mTORC1 is impaired in NUDT2-silenced cells. Mechanistically, NUDT2 binds to Rag GTPase and controls mTORC1 translocation to the lysosomal membrane. Furthermore, NUDT2-dependent mTORC1 regulation is critical for proliferation of breast cancer cells, as NUDT2-silenced cells arrest in G0/G1 phases. Taken together, these results show that NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control. ? 2017 Elsevier Inc. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.subject | heterodimer | - |
dc.subject | mammalian target of rapamycin complex 1 | - |
dc.subject | membrane protein | - |
dc.subject | nucleic acid binding protein | - |
dc.subject | nudix type motif 2 | - |
dc.subject | Rag guanosine triphosphatase | - |
dc.subject | unclassified drug | - |
dc.subject | Article | - |
dc.subject | breast cancer | - |
dc.subject | breast carcinogenesis | - |
dc.subject | cancer growth | - |
dc.subject | cell cycle checkpoint | - |
dc.subject | cell growth | - |
dc.subject | cell proliferation | - |
dc.subject | colony forming cell | - |
dc.subject | complex formation | - |
dc.subject | controlled study | - |
dc.subject | down regulation | - |
dc.subject | G0 phase cell cycle checkpoint | - |
dc.subject | G1 phase cell cycle checkpoint | - |
dc.subject | gene expression regulation | - |
dc.subject | gene silencing | - |
dc.subject | gene translocation | - |
dc.subject | lysosome membrane | - |
dc.subject | protein function | - |
dc.subject | protein localization | - |
dc.subject | protein protein interaction | - |
dc.subject | signal transduction | - |
dc.title | Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cellsig.2017.01.015 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.32, pp.24 - 35 | - |
dc.identifier.wosid | 000395953400003 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 35 | - |
dc.citation.startPage | 24 | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 32 | - |
dc.contributor.affiliatedAuthor | Suh, Pann-Ghill | - |
dc.contributor.affiliatedAuthor | Ryu, S.H. | - |
dc.identifier.scopusid | 2-s2.0-85010433455 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NUTRIENT-SENSING MECHANISMS | - |
dc.subject.keywordPlus | AMINO-ACID LEVELS | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | MTORC1 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | HYDROLASE | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | RAGULATOR | - |
dc.subject.keywordAuthor | Mammalian target of rapamycin complex 1 (mTORC1) | - |
dc.subject.keywordAuthor | Rag GTPases | - |
dc.subject.keywordAuthor | Nudix-type motif 2 (NUDT2) | - |
dc.subject.keywordAuthor | Lysosomal localization | - |
dc.subject.keywordAuthor | Cancer cell proliferation | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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